LymphedemaV1, France, Analysis, bibRecord, 000805

A prospective coagulation study including resistance to activated protein C and mutations in factors V and II in venous leg ulcers

Identifieur interne : 000805 ( France/Analysis ); précédent : 000804; suivant : 000806

A prospective coagulation study including resistance to activated protein C and mutations in factors V and II in venous leg ulcers

Auteurs : Eva M. Ribeaudeau ; Eva M. Senet ; Eva M. Cayuela ; Eva M. Fund ; Eva M. Paul ; Eva M. Robert ; Eva M. Scrobohaci [France] ; Eva M. Dubertret

Source :

British Journal of Dermatology [ 0007-0963 ] ; 1999-08.

RBID : ISTEX:542B6B5B796A37B364CCADF9D6FAEE149156CDC8

Abstract

Hypercoagulable states have been reported to be associated with venous leg ulcers. In an attempt to investigate the prevalence of hypercoagulable states in patients with venous leg ulcers, we performed a prospective case–control study for the presence of coagulation defects in such patients, including resistance to activated protein C (APC), factor V Leiden mutation and a newly described mutation in factor II. Results were compared with those obtained in a control group. APC resistance was found in four of 33 patients tested, but only one was found to be heterozygous for the factor V Leiden mutation. Factor II mutation was found in two of 30 patients tested. Our findings show that the prevalence of coagulation abnormalities is not different in patients with venous leg ulcers from controls in our study, suggesting that only selected patients with venous ulcers and a history of recurrent deep venous thrombosis should be investigated for the presence of coagulation defects.

Url:

https://api.istex.fr/document/542B6B5B796A37B364CCADF9D6FAEE149156CDC8/fulltext/pdf

DOI: 10.1046/j.1365-2133.1999.03026.x

Affiliations:

France

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to stream Istex, to step Corpus: 002691
to stream Istex, to step Curation: 002691
to stream Istex, to step Checkpoint: 003876
to stream Main, to step Merge: 00B573
to stream Main, to step Curation: 00AF55
to stream Main, to step Exploration: 00AF55
to stream France, to step Extraction: 000805

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ISTEX:542B6B5B796A37B364CCADF9D6FAEE149156CDC8

Le document en format XML

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<front><div type="abstract" xml:lang="en">Hypercoagulable states have been reported to be associated with venous leg ulcers. In an attempt to investigate the prevalence of hypercoagulable states in patients with venous leg ulcers, we performed a prospective case–control study for the presence of coagulation defects in such patients, including resistance to activated protein C (APC), factor V Leiden mutation and a newly described mutation in factor II. Results were compared with those obtained in a control group. APC resistance was found in four of 33 patients tested, but only one was found to be heterozygous for the factor V Leiden mutation. Factor II mutation was found in two of 30 patients tested. Our findings show that the prevalence of coagulation abnormalities is not different in patients with venous leg ulcers from controls in our study, suggesting that only selected patients with venous ulcers and a history of recurrent deep venous thrombosis should be investigated for the presence of coagulation defects.</div>
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A prospective coagulation study including resistance to activated protein C and mutations in factors V and II in venous leg ulcers

A prospective coagulation study including resistance to activated protein C and mutations in factors V and II in venous leg ulcers

Source :

Abstract

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